Role of beta-2-microglobulin as a biomarker in very preterm and extremely preterm infants with CNS inflammation

• DOI: 10.1371/journal.pone.0216498
• Publication Date: 2019-05-07T18:48:48Z
• Authors: Albert Batista Muñoz; Stephanie Hadley; Marti Iriondo Sanz; Thais Agut Quijano; Marta Camprubí Ca...
• Keywords: Beta-2 microglobulin; Viral meningitis

Background Premature infants are at risk for severe sepsis and meningitis, both infections associated with high mortality morbidity. Cerebro-spinal fluid (CSF) culture is the gold standard method meningitis diagnosis, but interpretation of biochemical parameters CSF essential moment analysis in order to start appropriate treatment. The main objective this study was determine whether levels beta-2-microglobulin (B2M) were elevated preterm CNS or other inflammatory processes, establish if there differences B2M concentrations amongst various settings (sepsis, progressive post-hemorrhagic ventricular dilatation (PHVD)). Methods This a retrospective all very extremely (< 32 weeks gestation) admitted our NICU between 2012 2017. All those who underwent lumbar puncture during their stay as part work-up PHVD considered inclusion. tested patients. Results Fifty-nine patients included study. In infections, median value 8.69 mg/L (3.92–18.5). above 3.92 showed greater sensitivity specificity than leukocyte discriminating processes without inflammation. Conclusions population, proved be an effective biomarker discriminate