Carnosine induces intestinal cells to secrete exosomes that activate neuronal cells

• DOI: 10.1371/journal.pone.0217394
• Publication Date: 2019-05-28T13:33:41Z
• Authors: Yuka Sugihara; Shiori Onoue; Kosuke Tashiro; Mikako Sato; Takanori Hasegawa; Yoshinori Katakura
• Keywords: Carnosine; Exosome; Neurite

Recently, we showed that imidazole dipeptide such as carnosine contained abundantly in chicken breast meat improves brain function a double-blind randomized controlled trial. However, the underlying molecular mechanisms remain unknown. Here, investigated whether activates intestinal epithelial cells and induces secretion of factors activate function. We focused on exosomes derived from mediators brain-gut interaction. Results Caco-2 treated with significantly induced neurite growth SH-SY5Y cells. To clarify basis this finding, performed integrated analysis microRNAs (miRNAs) altered expression response to treatment mRNAs target exosome identify related miRNAs their genes. The combination miR-6769-5p its gene ATXN1 was found be involved exosome-induced activation neuronal