A diet including xanthan gum triggers a pro-inflammatory response in Wistar rats inoculated with Walker 256 cells

• DOI: 10.1371/journal.pone.0218567
• Publication Date: 2019-06-18T17:33:08Z
• Authors: Alessandra B. Sil...; Nelson I. P. Neto; Karina Gascho; Marcela Carnier; Danielle A. de Mi...; Fernanda P. Silva; Valter T. Boldarine; Marília Seelaender; Eliane B. Ribeiro; Lila M. Oyama; Claudia M. Oller ...
• Keywords: Inflammation; Male; Science; Q; Polysaccharides, Bacterial; R; Cell Line; Diet; Rats; 03 medical and health sciences; 0302 clinical medicine; Area Under Curve; Medicine; Animals; Cytokines; Inflammation Mediators; Biomarkers; Cells, Cultured; Research Article

Objective The aim of this study was to evaluate the effect adding xanthan gum diet rats on production cytokines and pro-inflammatory factors tumor development in inoculated with Walker 256 cells. Methods Fifty-six were divided into 4 groups: control (C), (TC), (XG), (TXG). Results ingestion promotes changes cytokine content: increasing IL-6 TNF-α IL-10 retroperitoneal adipose tissue compared group; mesenteric C TXG groups. On contrary, addition did not affect tumors rats. Conclusion continuous use triggered a response, promoting an increase tissue, but it have animals