Fate of ptaquiloside—A bracken fern toxin—In cattle

• DOI: 10.1371/journal.pone.0218628
• Publication Date: 2019-06-21T17:30:41Z
• Authors: Paulo César dos R...; Lars Holm Rasmussen; Godelind Alma Wol...; Henrik Michael El...; Hans Christian Br...; Christian Friis
• Keywords: Bracken; Pteridium aquilinum

Ptaquiloside is a natural toxin present in bracken ferns (Pteridium sp.). Cattle ingesting may develop bladder tumours and excrete genotoxins meat milk. However, the fate of ptaquiloside cattle link between carcinogenesis unresolved. Here, we toxicokinetic profile plasma urine after intravenous administration oral bracken. Administered intravenously ptaquiloside, revealed volume distribution 1.3 L kg-1 with mean residence-time 4 hours. A large fraction was converted to non-toxic pterosin B blood stream. Both were excreted (up 41% dose). Oral via extract or dried did not result observations body fluids, indicating deglycosolidation rumen. Pterosin detected both administration. Hence, transport carcinogenic metabolites over rumen membrane indicated. recovered from counted for 7% dose given intravenously. Heifers exposed 7 days (2 mg kg-1) developed preneoplastic lesions urinary most likely caused by genotoxic metabolites.