Functional correlates of cognitive dysfunction in clinically isolated syndromes

• DOI: 10.1371/journal.pone.0219590
• Publication Date: 2019-07-17T17:31:30Z
• Authors: Sanuji Gajamange; Annie Shelton; Meaghan Clough; Owen White; Joanne Fielding; Scott Kolbe
• Keywords: Postcentral gyrus; Supramarginal gyrus; Clinically isolated syndrome

Cognitive dysfunction can be identified in patients with clinically isolated syndromes suggestive of multiple sclerosis using ocular motor testing. This study aimed to identify the functional neural correlates cognitive syndrome MRI. Eighteen and 17 healthy controls were recruited. Subjects underwent standard neurological neuropsychological also MRI (fMRI) during a task, involving pro-saccade (direct gaze towards target) anti-saccade away from trials. Ocular performance variables (averaged response time error rate) calculated for each subject. Patients showed trend greater rate errors (p = 0.09) compared controls. Compared controls, exhibited increased activation right postcentral, supramarginal gyrus, parietal operculum anti-saccade>pro-saccade contrast. demonstrated that changes organisation brain networks is associated subtle syndrome.