Staphylococcus pseudintermedius Sbi paralogs inhibit complement and bind IgM, IgG Fc and Fab

• DOI: 10.1371/journal.pone.0219817
• Publication Date: 2019-07-23T17:29:03Z
• Authors: Alaa H. Sewid; M. Nabil Hassan; A. M. Ammar; David A. Bemis; Stephen A. Kania
• Keywords: Staphylococcus pseudintermedius

The success of staphylococci as pathogens has been attributed, in part, to their ability evade hosts’ immune systems. Although the proteins involved evasion have extensively studied affecting humans little characterization done with Staphylococcus pseudintermedius, an important cause pyoderma dogs. aureus binder immunoglobulin (Sbi) interferes innate recognition by interacting multiple host proteins. In this study, a S. pseudintermedius gene that shares 38% similarity Sbi was cloned from strains representative major clonal lineages bearing two paralogs protein. Binding immunoglobulins and Fab Fc fragments well interaction complement measured. protein bound IgG species canine C3, neutralized activity IgM B cells. Evidence work suggests may play role evasion.