Physiological changes of growth hormone during lactation in pup rats artificially reared

• DOI: 10.1371/journal.pone.0220853
• Publication Date: 2019-08-13T17:31:02Z
• Authors: Cesar G. Toriz; Angel I. Melo; Carmen Solano-Agama; Edgar Giovanhi Gó...; Ma. de los Angele...; Jorge Castañeda-O...; Eunice Vera-Aguilar; Elsa Liliana Agui...; Lucero Romero-Agu...; Margarita Gonzále...; Ismael Jiménez-Es...; Maricela Luna; Juan Pablo Pardo; Javier Camacho; Maria Eugenia Men...
• Keywords: Maternal deprivation

During the lactation period, rat pups are fed by dam, and patterns of mother-pup interaction change during this period. Additionally, there changes in feeding; first, mother´s milk is only food needed for sustenance, later, it combined with solid water. GH serum concentrations depend on both maternal-pup energy metabolism. In artificial rearing (AR) procedure, deprived interaction, feeding pattern controlled. This paradigm has been used rats to analyze effects maternal deprivation social behavior. present study, we analyzed variation GH, acylated ghrelin IGF-1 throughout period AR pups. At pnd7, (MR) responded a 4 h fast drop concentration, which well-known response deprivation. levels did not change, suggesting an adaptation phenomenon. A dopamine inhibitory effect secretion was observed pnd7 cultured somatotropes, regulation at age. Acylated showed inverted compared that MR pups, related pattern. were lower than associated hepatic resistance low Igf1 mRNA expression pnd7. Interestingly, pnd14, pup groups high but levels, pnd21. However, glucose pnd14 reached same as Moreover, hepatomegaly higher GH-receptor pnd21, agreement absence meal. AR, lost interaction-stimulated secretion, correlated first week postnatal development. Later, exhibited responses, order satisfy metabolic demand normal weaning, carbohydrates their