Diversity of endocervical microbiota associated with genital Chlamydia trachomatis infection and infertility among women visiting obstetrics and gynecology clinics in Malaysia

• DOI: 10.1371/journal.pone.0224658
• Publication Date: 2019-11-18T18:38:11Z
• Authors: Heng Choon Cheong; Polly Soo Xi Yap; Chun Wie Chong; Yi Ying Cheok; Chalystha Yie Qin...; Grace Min Yi Tan; Sofiah Sulaiman; Jamiyah Hassan; Negar Shafiei Sabet; Chung Yeng Looi; Rishein Gupta; Bernard Arulanandam; Sazaly AbuBakar; Cindy Shuan Ju Teh; Li Yen Chang; Won Fen Wong
• Keywords: Prevotella; Sex organ

The cervical microbiota constitutes an important protective barrier against the invasion of pathogenic microorganisms. A disruption within milieu has been suggested to be a driving factor sexually transmitted infections. These include Chlamydia trachomatis which frequently causes serious reproductive sequelae such as infertility in women. In this study, we profiled microbial composition population 70 reproductive-age Malaysian women; among 40 (57.1%) were diagnosed with genital C. infection, and 30 (42.8%) without infection. Our findings showed distinct compositional difference between trachomatis-infected subjects Specifically, significant elevations mostly strict facultative anaerobes Streptococcus, Megasphaera, Prevotella, Veillonella trachomatis-positive women detected. results from current study highlights interaction environmental microbiome endocervical region.