Association of uric acid in serum and urine with subclinical renal damage: Hanzhong Adolescent Hypertension Study

• DOI: 10.1371/journal.pone.0224680
• Publication Date: 2019-11-15T18:53:55Z
• Authors: Yang Wang; Chen Chen; Yu Yan; Yue Yuan; Ke-Ke Wang; Chao Chu; Jia-Wen Hu; Qiong Ma; Yue-Yuan Liao; Bo-Wen Fu; Ke Gao; Yue Sun; Yong-Bo Lv; Wen-Jing Zhu; Lei Yang; Jie Zhang; Rui-Hai Yang; Jun Yang; Jian-Jun Mu
• Keywords: Subclinical infection

Background and objectives The aim of the study was to examine associations uric acid (UA) in blood urine with subclinical renal damage (SRD) its progression a Chinese cohort. Methods 1) 2342 participants from our previously established cohort who were followed up 2017 included. Cross-sectional analysis used relationships between serum urinary UA risk SRD. 2) A total 266 recruited same 2013, 2017. Longitudinal determine SRD, which defined as albumin-to-creatinine ratio (uACR) or estimated glomerular filtration rate (eGFR) decline. Results In cross-sectional analysis, higher levels uACR associated (SUA) acid/creatinine (uUA/Cre). Lower eGFR SUA fractional excretion (FEUA) but lower uUA/Cre all subjects. addition, multivariate-adjusted odds ratios for SRD compared non-SRD 3.574 (2.255–5.664) uUA/Cre. Increasing longitudinal 4-year changes significantly Conclusions This suggested that adults. Furthermore, progression. These findings suggest UA, especially may be simple, noninvasive marker early detection decreased function otherwise healthy