A neonatal nonhuman primate model of gestational Zika virus infection with evidence of microencephaly, seizures and cardiomyopathy

• DOI: 10.1371/journal.pone.0227676
• Publication Date: 2020-01-14T13:45:08Z
• Authors: Rosemary J. Stein...; Nicole N. Haese; Jessica L. Smith; Lois M. A. Colgin; Rhonda P. MacAlli...; Justin M. Greene; Christopher J. Pa...; J. Beth Kempton; Edward Porsov; Xiaojie Wang; Lauren M. Renner; Trevor J. McGill; Brandy L. Dozier; Craig N. Kreklywich; Takeshi F. Andoh; Marjorie R. Grafe; Heidi L. Pecoraro; Travis Hodge; Robert M. Friedman; Lisa A. Houser; Terry K. Morgan; Peter Stenzel; Jonathan R. Lindner; Robert L. Schelonka; Jonah B. Sacha; Victoria H. J. Ro...; Martha Neuringer; John V. Brigande; Christopher D. Kr...; Antonio E. Frias; Anne D. Lewis; Meredith A. Kelleher; Alec J. Hirsch; Daniel Neal Streblow
• Keywords: Zika Virus; Microcephaly; Ventriculomegaly; Cerebellar hypoplasia (non-human)

Zika virus infection during pregnancy is associated with miscarriage and a broad spectrum of fetal neonatal developmental abnormalities collectively known as congenital syndrome (CZS). Symptomology CZS includes malformations the brain skull, neurodevelopmental delay, seizures, joint contractures, hearing loss visual impairment. Previous studies in pregnant rhesus macaques (Macaca mulatta) have described injury to developing fetus loss, but outcomes following exposure yet be characterized nonhuman primates. Herein we describe presentation macaque neonates clinical outcomes, including one infant CZS-like symptoms cardiomyopathy, motor delay seizure activity maternal first trimester pregnancy. Further characterization this primate model gestational will provide opportunities evaluate efficacy pre- postnatal therapeutics for CZS.