Rapid glycemic regulation in poorly controlled patients living with diabetes, a new associated factor in the pathophysiology of Charcot’s acute neuroarthropathy

• DOI: 10.1371/journal.pone.0233168
• Publication Date: 2020-05-21T17:29:44Z
• Authors: Dured Dardari; Georges Ha Van; Jocelyne M’Bemba; Francois-Xavier L...; Olivier Bourron; Jean Michel Davaine; Franck Phan; Fabienne Foufelle; Frédéric Jaisser; Alfred Penfornis; Agnes Hartemann
• Keywords: Pathophysiology

Objective Aggressive antidiabetic therapy and rapid glycemic control are associated with diabetic neuropathy. Here we investigated if this is also the case for Charcot neuroarthropathy. Research design methods HbA1c levels other relevant data were extracted from medical databases of 44 cases acute Results significantly declined 8.25% (67mmol/mol) [7.1%–9.4%](54-79mmol/mol), at -6 months (M-6), to 7.40%(54mmol/mol) [6.70%–8.03%] (50–64 mmol/mol) during six preceding diagnosis neuroarthropathy (P <0.001). Conclusions onset This decline seems be a factor appearance an active phase in poorly controlled patients sensitive