Ferritin and C-reactive protein are predictive biomarkers of mortality and macrophage activation syndrome in adult onset Still’s disease. Analysis of the multicentre Gruppo Italiano di Ricerca in Reumatologia Clinica e Sperimentale (GIRRCS) cohort

• DOI: 10.1371/journal.pone.0235326
• Publication Date: 2020-07-09T17:28:13Z
• Authors: Paola Di Benedetto; Paola Cipriani; Daniela Iacono; Ilenia Pantano; Francesco Caso; Giacomo Emmi; Rosa Daniela Grem...; Francesco Paolo C...; Fabiola Atzeni; Federico Perosa; Raffaele Scarpa; Giuliana Guggino; Francesco Ciccia; Roberto Giacomelli; Piero Ruscitti
• Keywords: Macrophage Activation Syndrome

Objective To assess the predictive role of ferritin and C-reactive protein (CRP) on occurrence macrophage activation syndrome (MAS) mortality in patients with adult onset Still's disease (AOSD), a rare severe disease, included multicentre Gruppo Italiano di Ricerca Reumatologia Clinica e Sperimentale (GIRRCS) cohort. Methods The role, at time diagnosis, serum levels CRP MAS mortality, was evaluated by logistic regression analyses receiver-operating characteristic (ROC) curves were built to identify high risk respectively. Results In assessed 147 AOSD, (OR: 1.971; P: 0.002; CI 95%: 1.280–3.035). ROC curve showed that best cut-off for 1225 ng/ml predicting (sensitivity 88%; specificity 57%). Levels these 2.155; 0.007; 1.228–3.783). 68.7 mg/L 80%; 65%). Conclusions We reported respectively, large cohort identifying subsets higher poor prognosis. Considering analysis is widely available, results could be readily transferable into clinical practice, thus improving management AOSD.