Analysis of clinical features and early warning signs in patients with severe COVID-19: A retrospective cohort study

• DOI: 10.1371/journal.pone.0235459
• Publication Date: 2020-06-26T18:36:03Z
• Authors: Xinkui Liu; Xinpei Yue; Furong Liu; Le Wei; Yuntian Chu; Honghong Bao; Yichao Dong; Wenjie Cheng; Linpeng Yang
• Keywords: Adult; Male; China; Fever; Dyspnea ; COVID-19 ; C-reactive proteins ; Fevers ; Lymphocytes ; Cardiovascular diseases ; Pneumonia ; SARS ; Blood counts; Science; Pneumonia, Viral; Betacoronavirus; Leukocyte Count; 03 medical and health sciences; Extracorporeal Membrane Oxygenation; 0302 clinical medicine; Predictive Value of Tests; Humans; Pandemics; Aged; Q; R; Age Factors; COVID-19; Middle Aged; 3. Good health; Hospitalization; Logistic Models; Multivariate Analysis; Medicine; Female; Coronavirus Infections; Research Article

Coronavirus disease 2019 (COVID-19) was first identified in Wuhan, China, December 2019. Although previous studies have described the clinical aspects of COVID-19, few focused on early detection severe COVID-19. Therefore, this study aimed to identify predictors COVID-19 and compare features between patients with those less Patients admitted designated hospital Henan Province China who were either discharged or died prior February 15, 2020 enrolled retrospectively. Additionally, underwent at least one following treatments assigned group: continuous renal replacement therapy, high-flow oxygen absorption, noninvasive invasive mechanical ventilation, extracorporeal membrane oxygenation. The remaining non-severe group. Demographic information, initial symptoms, visit examination results collected from electronic medical records compared groups. Multivariate logistic regression analysis performed determine A receiver operating characteristic curve used a threshold for each predictor. Altogether,104 our 30 74 groups, respectively. indicated that aged ≥63 years (odds ratio = 41.0; 95% CI: 2.8, 592.4), an absolute lymphocyte value ≤1.02×109/L 6.1; CI 1.5, 25.2) C-reactive protein level ≥65.08mg/L 8.9; 1.0, 74.2) higher risk illness. Thus, could be helpful illness, enabling implementation effective interventions likely lowering morbidity patients.