Litter expansion alters metabolic homeostasis in a sex specific manner

• DOI: 10.1371/journal.pone.0237199
• Publication Date: 2021-09-29T19:29:25Z
• Authors: Kavitha Kurup; Shivani N. Mann; Jordan Jackson; Stephanie Matyi; Michelle Ranjo-Bi...; Willard M. Freeman; Michael B. Stout; Arlan Richardson; Archana Unnikrishnan
• Keywords: Litter

Nutritional manipulations early in life have been shown to influence growth rate and elicit long lasting effects which turn has found impact lifespan. Therefore, we studied the long-term of pre-weaning dietary restriction implemented by litter expansion (4, 6, 8, 10, 12 pups per dam: LS4, LS6, LS8, LS10, LS12) on male female C57BL/6J mice. After weaning, these mice were fed ad libitum a commercial lab chow for 15-month duration study. The from large size (LS12) significantly leaner had reduced total fat mass compared normal litters (LS 6) starting weaning through 15 months age. Male LS10 & also showed significant reduction their depot masses at age: gonadal, subcutaneous, brown whereas females did not mimic findings. At 9 age, only LS12 improved glucose tolerance insulin 5 In addition, that 10 age IGF-1 levels serum various other organs (liver, gastrocnemius brain cortex). Interestingly, different pattern with serum, liver but cortex. Similarly, expanded sex specific response FGF21 adiponectin showing increased summary, our data show that, results long-lasting metabolic changes are dependent an robust