Mediterranean diet and quality of life in women treated for breast cancer: A baseline analysis of DEDiCa multicentre trial

• DOI: 10.1371/journal.pone.0239803
• Publication Date: 2020-10-08T17:55:56Z
• Authors: Giuseppe Porciello; Concetta Montagnese; Anna Crispo; Maria Grimaldi; Massimo Libra; Sara Vitale; Elvira Palumbo; Rosa Pica; Ilaria Calabrese; Serena Cubisino; Luca Falzone; Luigina Poletto; Valentina Martinuzzo; Melania Prete; Nadia Esindi; Guglielmo Thomas; Daniela Cianniello; Monica Pinto; Michelino De Laur...; Carmen Pacilio; Massimo Rinaldo; Massimiliano D’Aiuto; Diego Serraino; Samuele Massarut; Chiara Evangelista; Agostino Steffan; Francesca Catalano; Giuseppe L. Banna; Giuseppa Scandurra; Francesco Ferraù; Rosalba Rossello; Giovanna Antonelli; Gennaro Guerra; Amalia Farina; Francesco Messina; Gabriele Riccardi; Davide Gatti; David J. A. Jenkins; Anita Minopoli; Bruna Grilli; Ernesta Cavalcanti; Egidio Celentano; Gerardo Botti; Maurizio Montella; Livia S. A. Augustin
• Keywords: Mediterranean Diet

Evidence suggests a beneficial role of the Mediterranean Diet (MedDiet) on health-related quality life (HRQoL) in healthy subjects. HRQoL is relevant cancer therapy and disease outcomes, therefore we investigated association between adherence to MedDiet breast survivors participating multicentre trial DEDiCa. were assessed at baseline subgroup 309 women enrolled within 12 months diagnosis without metastasis (stages I-III, mean age 52±1 yrs, BMI 27±7 kg/m2). The 14-item PREDIMED questionnaire was used analyse MedDiet. with three validated questionnaires measuring physical, mental, emotional social factors: EQ-5D-3L, EORTC QLQ-C30 QLQ-BR23. Analysis variance (ANOVA) multivariate analyses performed assess possible HRQoL. Patients higher (PREDIMED score >7) showed significantly scores for physical functioning (p = 0.02) lower symptomatic pain scale 0.04) by compared patients ≤7). Higher from EQ-5D-3L indicating well-being observed mainly participants 0.05). In adjusted significant positive associations found MedDiet, 0.001) EQ 5D-3L 0.003) while inverse insomnia symptoms 0.005 p 0.029, respectively). These results suggest that associated better aspects life, specifically functioning, sleep, generally confirming findings