Prometheus, an omics portal for interkingdom comparative genomic analyses

• DOI: 10.1371/journal.pone.0240191
• Publication Date: 2020-10-28T17:27:30Z
• Authors: Gunhwan Ko; Insu Jang; Namjin Koo; Seong-Jin Park; Sang-Ho Oh; Min-Seo Kim; Jin-Hyuk Choi; Hyeongmin Kim; Young Mi Sim; Iksu Byeon; Pan-Gyu Kim; Kye Young Kim; Jong-Cheol Yoon; Kyung-Lok Mun; Banghyuk Lee; Gukhee Han; Yong-Min Kim
• Keywords: Identification; Gene prediction; Functional Genomics

Functional analyses of genes are crucial for unveiling biological responses, genetic engineering, and developing new medicines. However, functional have largely been restricted to model organisms, representing a major hurdle studies industrial applications. To resolve this, comparative genome can be used provide clues gene functions as well their evolutionary history. this end, we present Prometheus, web-based omics portal that contains more than 17,215 sequences from prokaryotic eukaryotic genomes. This supports interkingdom via domain architecture-based identification system Gene Search, users easily rapidly identify single or entire sets in specific pathways. Bioinformatics tools further provided Prometheus through Bio-Express, cloud-based bioinformatics analysis platform. is paradigm large amounts genomic information.