Angiography with optical coherence tomography as a biomarker in multiple sclerosis

• DOI: 10.1371/journal.pone.0243236
• Publication Date: 2020-12-08T21:03:12Z
• Authors: Beatriz Cordon; Elisa Vilades; Elvira Orduna; María Satue; Javier Perez-Velilla; Berta Sebastian; Vicente Polo; Jose Manuel Larrosa; Luis Emilio Pablo; Elena Garcia-Martin
• Keywords: Optic neuritis

Purpose To investigate superficial retinal microvascular plexuses detected by optical coherence tomography angiography (OCT-A) in multiple sclerosis (MS) subjects and compare them with healthy controls. Methods A total of 92 eyes from patients relapsing-remitting MS 149 control were included this prospective observational study. OCT-A imaging was performed using Triton Swept-Source OCT (Topcon Corporation, Japan). The vessel density (VD) percentage the plexus optic disc area (6 x 6 mm grid) measured compared between groups. Results showed a significant decrease VD superior (p = 0.005), nasal 0.029) inferior 0.040) parafoveal retina subjects. Patients disease durations more than 5 years presented lower 0.002), 0.017) 0.022) areas past neuritis episodes did not show microvasculature alterations, but an EDSS score less 3 0.024) 0.006) perifoveal when Conclusions produces vascularization retina. Alterations observed are independent presence nerve inflammation. has ability to detect subclinical vascular changes is potential biomarker for diagnosing progression MS.