Epidemiology, outcomes, and the use of intensive care unit resources of critically ill patients diagnosed with COVID-19 in Sao Paulo, Brazil: A cohort study

• DOI: 10.1371/journal.pone.0243269
• Publication Date: 2020-12-03T18:58:50Z
• Authors: Rachel Lane Socol...; Renata Rego Lins ...; Bruno Martins Tom...; Laerte Pastore; Filomena Regina B...; Luciano Cesar Pon...; Eduardo Leite Vie...
• Keywords: 2019-20 coronavirus outbreak

The coronavirus disease (COVID-19) pandemic has brought significant challenges worldwide, with high mortality, increased use of hospital resources, and the collapse healthcare systems. We aimed to describe clinical outcomes critically ill COVID-19 patients assess impact on resources compare medical without COVID-19.In this retrospective cohort study, we included diagnosed admitted a private ICU in Sao Paulo, Brazil from March June 2020. compared these those unit same period previous year. A total 212 consecutive confirmed diagnosis were 185 Patients more frequently males (76% vs. 56%, p<0.001) morbidly obese (7.5% 2.2%, p = 0.027), had lower SAPS 3 (49.65 (12.19) 55.63 (11.94), SOFA scores (3.78 (3.53) 4.48 (3.11), 0.039). longer stay (median 7 days, p<0.001), duration mechanical ventilation 9 4 0.003), frequent tracheostomies (10.8 1.1%, p<0.001). Survival rates until 28 days not statistically different (91% 85.4%, 0.111). After multivariable adjustment for age, gender, 3, Charlson Comorbidity Index, remained associated survival at (HR 0.59, 95% CI 0.33-1.06, 0.076). Among who underwent invasive ventilation, observed mortality 28-days was 16.2% 34.6% year.COVID-19 required including non-invasive prolonged length stay. There no difference all-cause 60 suggesting that health systems preparedness be an important determinant outcomes.