Abnormal neuroinflammation in fibromyalgia and CRPS using [11C]-(R)-PK11195 PET

• DOI: 10.1371/journal.pone.0246152
• Publication Date: 2021-02-08T23:07:07Z
• Authors: Seongho Seo; Ye-Ha Jung; Dasom Lee; Won Joon Lee; Joon Hwan Jang; Jae-Yeon Lee; Soo-Hee Choi; Jee Youn Moon; Jae Sung Lee; Gi Jeong Cheon; Do-Hyung Kang
• Keywords: Postcentral gyrus

Purpose Fibromyalgia (FM) and complex regional pain syndrome (CRPS) share many pathological mechanisms related to chronic neuroinflammation, which may contribute the multifactorial in both FM CRPS. The aim of this study was assess neuroinflammation patients compared with that CRPS healthy controls. Methods Neuroinflammation measured as distribution volume ratio (DVR) [ 11 C]-(R)-PK11195 positron emission tomography (PET) 12 patients, 15 Results significantly higher left pre (primary motor cortex) post somatosensory central gyri (p < 0.001), right postcentral gyrus 0.005), superior parietal frontal precuneus 0.01), medial = 0.036) Furthermore, DVR demonstrated decreased medulla temporal amygdala 0.020) Conclusions To authors’ knowledge, report is first describe abnormal levels brains using PET. results suggested can be an important factor FM. In addition, identification common different critical regions FM, controls, improved diagnosis development effective medical treatment for