The role of quantitative diffusion-weighted imaging in characterization of hypovascular liver lesions: A prospective comparison of intravoxel incoherent motion derived parameters and apparent diffusion coefficient

• DOI: 10.1371/journal.pone.0247301
• Publication Date: 2021-02-20T02:50:29Z
• Authors: Jelena Djokić Kovač; Marko Daković; Aleksandra Janković; Milica Mitrović; Vladimir Dugalić; Daniel Galun; Aleksandra Đurić-...; Dragan Mašulović
• Keywords: Intravoxel incoherent motion

Background The utility of intravoxel incoherent motion (IVIM) related parameters in differentiation hypovascular liver lesions is still unknown. Purpose purpose this study was to evaluate the value IVIM comparison apparent diffusion coefficient (ADC) for among intrahepatic mass-forming cholangiocarcinoma (IMC), and metastases (HLM). Methods Seventy-four prospectively enrolled patients (21 IMC, 53 HLM) underwent 1.5T magnetic resonance examination with diffusion-weighted imaging using seven b values (0–800 s/mm 2 ). Two independent readers performed quantitative analysis IVIM-related ADC. Interobserver reliability tested a intraclass correlation coefficient. ADC, true ( D ), perfusion-related *), perfusion fraction (ƒ) were compared Kruskal-Wallis H test. diagnostic accuracy each parameter assessed by receiver operating characteristic (ROC) curve analysis. Results interobserver agreement good ADC (0.802), excellent , *, ƒ (0.911, 0.927, 0.942, respectively). significantly different IMC HLM (both p < 0.05), while there no significant difference these * = 0.101, 0.612, ROC showed higher performance (AUC 0.879 vs 0.821). Conclusion IVIM-derived particular addition could help between most common malignant lesions, mass—forming metastases.