Relationships between depression and anxiety symptoms and adipocyte-derived proteins in postmenopausal women

• DOI: 10.1371/journal.pone.0248314
• Publication Date: 2021-03-05T18:38:15Z
• Authors: Yu-Ting Wu; Wan-Yu Huang; Chew-Teng Kor; Ko-Hung Liu; Ting-Yu Chen; Po-Te Lin; Hung-Ming Wu
• Keywords: Depression

Introduction Studies on the association between adiponectin and leptin anxiety depression among postmenopausal women are limited. Therefore, present study specifically evaluates mutual relationships in women. Participants design In this cross-sectional study, a total of 190 aged 40–65 years were enrolled. Depression symptoms assessed using Center for Epidemiologic Scale (CES-D), evaluated Hamilton Anxiety Rating (HAM-A). Fasting specimens collected to measure sex hormone, glucose, insulin, adipokine levels. Multiple linear regression analysis was performed evaluate associations adipocyte-derived hormones. Settings The hospital medical center. Results Among enrolled women, Spearman’s rank correlation revealed significant correlations CES-D HAM-A (r = 0.715, P < 0.0001), ( p 0.009) 0.015), 0.01) 0.001). subjects with ≥ 16 18 had higher levels than those 18, respectively. After adjusting age, body mass index, exercise, alanine amino transferase parameters lipid profiles, Log found be significantly associated both HAM-A, only HAM-A. Conclusions data show that symptoms. These results suggest lower may serve as potential markers related mood More future research is designed deal important confounders (e.g., population heterogeneity) needed investigate comprehensively these associations.