Utility of Fatty Liver Index to predict reversion to normoglycemia in people with prediabetes

• DOI: 10.1371/journal.pone.0249221
• Publication Date: 2021-04-06T17:25:00Z
• Authors: Carla Busquets-Co...; Miquel Bennasar-Veny; Ángel Arturo Lópe...; Sergio Fresneda; Manuela Abbate; Aina M. Yáñez
• Keywords: Prediabetes; Steatosis; Reversion; Impaired fasting glucose

Background Fatty Liver Index (FLI) is strongly associated with changes in glycemic status and incident Type 2 Diabetes (T2D). The probability of reverting to normoglycemia from a state prediabetes could be determined by FLI, however such relationship remains poorly understood. Aim To determine the clinical interest using FLI estimate reversion at 5 years patients impaired fasting plasma glucose baseline, identify those factors that contribute prediabetes. Methods This 5-year cohort study included 16,648 Spanish working adults Prediabetes was defined as (FPG) between 100 125 mg/dl according ADA criteria, while FPG <100 mg/dL. population classified as: <30 (no hepatic steatosis), 30–59 (intermediate status), ≥60 (hepatic steatosis). Results At follow-up, 33.7% subjects reverted (annual rate 6.7%). adjusted binomial logistic regression model showed scoring (OR 1.544; 95% CI 1.355–1.759), performing least 150 min/week physical activity 4.600; 4.088–5.177) consuming fruits vegetables daily 1.682; 1.526–1.855) were form normoglycemia. ROC curve for prediction (AUC 0.774;95% 0.767–0.781) better predictor than 0.656; 0.648–0.664). Conclusions Regular activity, healthy dietary habits absence steatosis are independently adult workers baseline. Low values (especially FLI< 30) may useful predict reversion, especially active eating habits, thus who might benefit early lifestyle intervention.