Prevalence and factors associated with psychological burden in COVID-19 patients and their relatives: A prospective observational cohort study

• DOI: 10.1371/journal.pone.0250590
• Publication Date: 2021-05-05T19:29:16Z
• Authors: Katharina Beck; Alessia Vincent; Christoph Becker; Annalena Keller; Hasret Cam; Rainer Schaefert; Thomas Reinhardt; Raoul Sutter; Kai Tisljar; Stefano Bassetti; Philipp Schuetz; Sabina Hunziker
• Keywords: 2019-20 coronavirus outbreak; Betacoronavirus

Background Due to the dramatic measures accompanying isolation and general uncertainty fear associated with COVID-19, patients relatives may be at high risk for adverse psychological outcomes. Until now there has been limited research focusing on prevalence of distress factors in COVID-19 their relatives. The objective our study was assess 30 days after hospital discharge. Methods In this prospective observational cohort two Swiss tertiary-care hospitals we included consecutive adult hospitalized between March June 2020 a proven Psychological defined as symptoms anxiety and/or depression measured Hospital Anxiety Depression Scale (HADS), i.e., score ≥8 subscale. We further evaluated post-traumatic stress disorder (PTSD), ≥1.5 Impact Event Scale-Revised (IES-R). Results Among 126 patients, 24 (19.1%) had 10 (8.7%) PTSD multivariate logistic regression analyses three were independently patients: resilience (OR 0.82; 95%CI 0.71 0.94; p = 0.005), levels perceived 1.21; 1.06 1.38; 0.006) low frequency contact 7.67; 1.42 41.58; 0.018). model showed good discrimination, an area under receiver-operating characteristic curve (AUC) 0.92. 153 relatives, 35 (22.9%) distress, 3 (2%) PTSD. For negatively 0.85; 0.75 0.96; 0.007), whereas overall burden caused by positively 1.72; 1.31 2.25; p<0.001). also AUC 0.87. Conclusion A relevant number well exhibited These results might aid development strategies prevent