Does varying the ingestion period of sodium citrate influence blood alkalosis and gastrointestinal symptoms?

• DOI: 10.1371/journal.pone.0251808
• Publication Date: 2021-05-17T17:28:19Z
• Authors: Charles S. Urwin; Rodney J. Snow; Liliana Orellana; Dominique Condo; Glenn D. Wadley; Amelia J. Carr
• Keywords: Adult; Male; Gastrointestinal Diseases; Science; Q; R; 610; Alkalosis; Sodium Citrate; 630; 3. Good health; Bicarbonates; 03 medical and health sciences; 0302 clinical medicine; Medicine; Humans; Female; Exercise; Research Article

Objectives To compare blood alkalosis, gastrointestinal symptoms and indicators of strong ion difference after ingestion of 500 mg.kg-1 BM sodium citrate over four different periods.

Methods Sixteen healthy and active participants ingested 500 mg.kg-1 BM sodium citrate in gelatine capsules over a 15, 30, 45 or 60 min period using a randomized cross-over experimental design. Gastrointestinal symptoms questionnaires and venous blood samples were collected before ingestion, immediately post-ingestion, and every 30 min for 480 min post-ingestion. Blood samples were analysed for blood pH, [HCO3-], [Na+], [Cl-] and plasma [citrate]. Linear mixed models were used to estimate the effect of the ingestion protocols.

Results For all treatments, blood [HCO3-] was significantly elevated above baseline for the entire 480 min post-ingestion period, and peak occurred 180 min post-ingestion. Blood [HCO3-] and pH were significantly elevated above baseline and not significantly below the peak between 150–270 min post-ingestion. Furthermore, blood pH and [HCO3-] were significantly lower for the 60 min ingestion period when compared to the other treatments. Gastrointestinal symptoms were minor for all treatments; the mean total session symptoms ratings (all times summed together) were between 9.8 and 11.6 from a maximum possible rating of 720.

Conclusion Based on the findings of this investigation, sodium citrate should be ingested over a period of less than 60 min (15, 30 or 45 min), and completed 150–270 min before exercise.