Availability of preoperative neutrophil-lymphocyte ratio to predict postoperative delirium after head and neck free-flap reconstruction: A retrospective study

• DOI: 10.1371/journal.pone.0254654
• Publication Date: 2021-07-13T18:16:29Z
• Authors: Hirotaka Kinoshita; Junichi Saito; Daiki Takekawa; Tasuku Ohyama; Tetsuya Kushikata; Kazuyoshi Hirota
• Keywords: Interquartile range; Univariate analysis

Postoperative delirium (POD) is a well-recognized postoperative complication and associated with increased morbidity mortality. We investigated whether the preoperative neutrophil-lymphocyte ratio (NLR) could be an effective predictor of POD after head neck free-flap reconstruction. This was single-center, retrospective, observational study. analyzed perioperative data patients who had undergone elective reconstruction surgery. assessed Intensive Care Delirium Screening Checklist (ICDSC) during admission to our intensive care unit (ICU). defined as ICDSC score ≥4. Risk factors for were evaluated by univariate multivariate logistic regression analysis. included 97 patients. The incidence 20.6% (20/97). Significantly longer ICU stays observed in compared those without (median [interquartile range]: 5 [4-6] vs. 4 [4-5], p = 0.031). Higher NLR values (3 <NLR ≤4 <NLR) significantly higher scores ≤1 (4 [2-4] 1 [1-1], 0.027 [1-4] 0.038, respectively). multivariable analysis revealed that only >3.0 (adjusted Odds Ratio: 23.6, 95% Confidence Interval: 6.6-85.1; p<0.001) independently POD. area under receiver operator curve greater E-PRE-DELIRIC model (0.87 0.60; p<0.001). may good undergoing