Yield of tumor samples with a large guide-sheath in endobronchial ultrasound transbronchial biopsy for non-small cell lung cancer: A prospective study

• DOI: 10.1371/journal.pone.0259236
• Publication Date: 2021-10-29T17:25:45Z
• Authors: Naoko Katsurada; Motoko Tachihara; Naoe Jimbo; Masatsugu Yamamoto; Junya Yoshioka; Chihiro Mimura; Hiroki Satoh; Koichi Furukawa; Takehiro Otoshi; Tatsunori Kiriu; Yuichiro Yasuda; Tomonori Tanaka; Tatsuya Nagano; Yoshihiro Nishimura
• Keywords: Endobronchial ultrasound

Background Adequate tumor tissue is required to make the best treatment choice for non-small cell lung cancer (NSCLC). Transbronchial biopsy (TBB) by endobronchial ultrasonography with a guide sheath (EBUS-GS) useful diagnose peripheral lesions. The data of numbers obtained two different sizes GSs limited. We conducted this study investigate utility large GS kit obtain many cells in patients NSCLC. Methods Patients lesion and suspected NSCLC were prospectively enrolled. They underwent TBB 5.9-mm diameter bronchoscope GS. When was invisible EBUS, we changed thinner performed small compared number (prospective group) those previously (small cohort). primary endpoint per sample, assessed characteristics lesions that could be Results Biopsy 55 87 (63.2%), 37 diagnosed based on histological samples. sample not between groups (658±553 vs. 532±526, estimated difference 95% confidence interval (CI); 125 (-125–376), p = 0.32). size group significantly larger than cohort (1.75 mm 2 0.83 , CI; 0.92 (0.60–1.23) 0.00000019). involving third or less bronchus generation predictive factors using Conclusions GS, but there no significant number. can used generation.