Physical exercise is associated with a reduction in plasma levels of fractalkine, TGF-β1, eotaxin-1 and IL-6 in younger adults with mobility disability

• DOI: 10.1371/journal.pone.0263173
• Publication Date: 2022-02-03T18:49:28Z
• Authors: Parvin Kumar; Miranda Stiernborg; Anna Fogdell-Hahn; Kristoffer Månsson; Tomas Furmark; Daniel Berglind; Philippe A. Melas; Yvonne Forsell; Catharina Lavebratt
• Keywords: Aerobic Exercise

Mobility disability (MD) refers to substantial limitations in life activities that arise because of movement impairments. Although MD is most prevalent older individuals, it can also affect younger adults. Increasing evidence suggests inflammation drive the development and may need be targeted for prevention. Physical exercise has anti-inflammatory properties been associated with However, no studies date have examined whether interventions peripheral inflammatory status adults MD. To this end, we used blood samples from young middle-aged (N = 38; median age 34 years) who participated a 12-week intervention included aerobic resistance training. A pre-post assessment biomarkers was conducted plasma two timepoints, i.e., before trial at follow-up (3–7 days after last session). We successfully measured 15 found significant reduction levels soluble fractalkine, transforming growth factor beta 1 (TGF-β1), eotaxin-1 interleukin (IL) 6 (corrected α 0.004). male-specific effects on (i) increasing IL-16 (ii) decreasing vascular endothelial factor-A (VEGF-A). In line our results, previous reduce TGF-β1, IL-6. finding reduces fractalkine MD, as well sex-dependent findings, not previously reported warrant replication larger cohorts. Given suggested role promoting development, study provides additional support use physical treatment modality