Different patterns of white matter microstructural alterations between psychotic and non-psychotic bipolar disorder

• DOI: 10.1371/journal.pone.0265671
• Publication Date: 2022-03-18T20:05:20Z
• Authors: Dong-Kyun Lee; Hyeongrae Lee; Vin Ryu; Sung-Wan Kim; Seunghyong Ryu
• Keywords: Corona radiata (embryology); Cingulum (brain); Fornix; External capsule

This study aimed to investigate alterations in white matter (WM) microstructure patients with psychotic and non-psychotic bipolar disorder (PBD NPBD, respectively). We used 3T-magnetic resonance imaging examine 29 PBD, 23 65 healthy control (HC) subjects. Using tract-based spatial statistics for diffusion tensor data, we compared fractional anisotropy (FA) mean (MD) pairwise among the HC groups. found several WM areas of decreased FA or increased MD PBD NPBD groups HC. showed widespread decreases corpus callosum as well bilateral internal capsule fornix. However, local a part body limited regions within left cerebral hemisphere, including anterior posterior corona radiata cingulum. In addition, both shared increases across radiata, cingulum, sagittal stratum. These findings suggest that microstructural might be common neuroanatomical characteristic disorder, regardless being non-psychotic. Particularly, involve extensive inter-and intra-hemispheric connectivity disruptions.