Association between intraoperative end-tidal carbon dioxide and postoperative organ dysfunction in major abdominal surgery: A cohort study

• DOI: 10.1371/journal.pone.0268362
• Publication Date: 2023-03-10T18:29:18Z
• Authors: Li Dong; Chikashi Takeda; Tsukasa Kamitani; Miho Hamada; Akiko Hirotsu; Yosuke Yamamoto; Toshiyuki Mizota
• Keywords: Organ dysfunction

Data on the effects of intraoperative end-tidal carbon dioxide (EtCO2) levels postoperative organ dysfunction are limited. Thus, this study was designed to investigate relationship between EtCO2 level and in patients who underwent major abdominal surgery under general anesthesia.We conducted a cohort involving anesthesia at Kyoto University Hospital. We classified those with mean less than 35 mmHg as low EtCO2. The time effect determined minutes when value below mmHg, whereas cumulative evaluated by measuring area 35-mmHg threshold. outcome dysfunction, defined composite least one among acute renal injury, circulatory respiratory coagulation liver within 7 days after surgery.Of 4,171 patients, 1,195 (28%) had EtCO2, 1,428 (34%) dysfunction. An association found increased (adjusted risk ratio, 1.11; 95% confidence interval [CI], 1.03-1.20; p = 0.006). Additionally, long-term exposure values (≥224 min) associated 1.18; CI, 1.06-1.32; 0.003) severity (area threshold) 1.13; 1.02-1.26; 0.018).Intraoperative