Relationship between blood manganese and bone mineral density and bone mineral content in adults: A population-based cross-sectional study

• DOI: 10.1371/journal.pone.0276551
• Publication Date: 2022-10-21T17:29:19Z
• Authors: Chao Wang; Yong Zhu; Haitao Long; Mingning Ou; Shushan Zhao
• Keywords: Cross-sectional study; Bone mineral content

Purpose It has been reported that bone is the primary organ for manganese (Mn) accumulation, but association between and loss remains debatable. Therefore, this study aimed to evaluate relationship blood mineral density/bone content (BMD/BMC) by using a representative sample from National Health Nutrition Examination Survey (NHANES). Methods A total of 9732 subjects over age 18 with available data were enrolled in study. The BMD/BMC body, spine femoral regions was evaluated multivariate linear regression models. Subgroup analyses also performed. Results We observed negative neck body fully adjusted model, especially BMD women aged 50–70 years. Conclusion In brief, people exposed should be aware increased risk osteopenia or osteoporosis. Besides, due lack data, there are no definite values tolerable upper intake level (UL), average requirement (AR) population reference (PRI) manganese. results our may provide some references establishment AR, PRI UL Mn.