Nasopharyngeal colonization by Streptococcus pneumoniae in children and adults before the introduction of the 10-valent conjugate vaccine, Paraguay

• DOI: 10.1371/journal.pone.0280722
• Publication Date: 2023-02-16T18:29:12Z
• Authors: Gustavo Chamorro; Aníbal Kawabata; María da Gloria C...; Fabiana C. Pimenta; Fernanda C. Lessa; Carlos Torres; María José Lerea; María Eugenia León
• Keywords: Pneumococcal Conjugate Vaccine; Conjugate; Pneumococcal infections

Streptococcus pneumoniae is a cause of invasive diseases such as pneumonia, meningitis, and other serious infections among children adults in Paraguay. This study was conducted to establish S . baseline prevalence, serotype distribution, antibiotic resistance patterns healthy aged 2 59 months ≥60 years age prior the introduction PCV10 national childhood immunization program Between April July 2012, total 1444 nasopharyngeal swabs were collected, 718 from 726 age. The pneumococcal isolation, serotyping, susceptibility testing performed using standard tests. Pneumococcal colonization prevalence 34.1% (245/718) 3.3% (24/726) adults. most frequent vaccine-types (VT) detected 6B (42/245), 19F (32/245), 14 (17/245), 23F (20/245). Carriage with serotypes 50.6% (124/245) PCV13 59.5% (146/245). Among colonized adults, 29.1% (7/24) 41.6% (10/24), respectively. Colonized more likely share bedroom, have history respiratory infection or compared non-colonized children. no associations found However, significant neither Vaccine-type highly prevalent rare Paraguay vaccine introduction, supporting country 2012. These data will be useful evaluate impact PCV country.