Prognostic accuracy of qSOFA score, SIRS criteria, and EWSs for in-hospital mortality among adult patients presenting with suspected infection to the emergency department (PASSEM) Multicenter prospective external validation cohort study protocol

• DOI: 10.1371/journal.pone.0281208
• Publication Date: 2024-01-17T18:28:40Z
• Authors: Abdullah M. Algarni; Musa S. Alfaifi; Ali A. Al Bshabshe; Othman M. Omair; Mohammed A. Alsultan; Hasan M. Alzahrani; Hadi E. Alali; Abdullah A. Alsab...; Ali M. Alqarni; Salah A. Alghanem; Bandar S. Al Mufareh; Ayesha M. Almemari; Abdulrahman A. Sindi; Ibrahim U. Ozturan; Abdullah A. Alhad...; Asaad S. Shujaa; Abdullah H. Alotaibi; Moosa M. Awladthani; Ahmed A. Alsaad; Abdullah A. Almar...; AlHanouv M. AlQah...; Tim R. Harris; Bader A. Alyahya; Saad A. Assiri; Feras H. Abuzeyad; Sara N. Kazim; Abdulrahman A. Al...; Faisal Y. Almazroua; Naif T. Marzook; Abdullah A. Basri; Abdallah M. Elsafti; Abdulaziz S. Alal...; Cansu A. Özturan; Yousef I. Alawad; Awad AlOmari; Malek A. Alkhateeb; Moonis M. Farooq; Latifa Ali AlMutairi; Muneera M. Alasfour; Mohammad I. Al Haber; Umma-Kulthum A. Umar; Nidal H. Bokhary; Saeed F. Alqahtani; Abdulrhman Almutairi; Hisham F. Alyahya; Wejdan S. Alzahrani; Fawziah Alsalmi; Abdulmajeed M. Omair; Faysal M. Alasmari; Sultan Y. Alfifi; Mohammed S. Al-Nu...; Farid Foroutan
• Keywords: Mews; Triage; Vital signs; SOFA score

Background Early identification of a patient with infection who may develop sepsis is utmost importance. Unfortunately, this remains elusive because no single clinical measure or test can reflect complex pathophysiological changes in patients sepsis. However, multiple and laboratory parameters indicate impending organ dysfunction. Screening tools using these help identify the condition, such as SIRS, quick SOFA (qSOFA), National Warning Score (NEWS), Modified (MEWS). We aim to externally validate qSOFA, NEWS/NEWS2/MEWS for in-hospital mortality among adult suspected presenting emergency department. Methods analysis PASSEM study an international prospective external validation cohort study. For 9 months, each participating center will recruit consecutive visited departments are planned hospitalization. collect patients’ demographics, vital signs measured triage, initial white blood cell count, variables required calculate Charlson Comorbidities Index; follow 90 days since their inclusion The primary outcome be 30-days mortality. secondary intensive care unit (ICU) admission, prolonged stay ICU (i.e., ≥72 hours), 30- well 90-days all-cause started December 2021 enroll 2851 reach 200 death. sample size adaptive adjusted based on prespecified interim analyses. Discussion first multicenter that designated qSOFA score, SIRS criteria, EWSs ED Middle East region. Study registration registered at ClinicalTrials.gov ( NCT05172479 ).