Tuberculosis notifications in regional Victoria, Australia: Implications for public health care in a low incidence setting

• DOI: 10.1371/journal.pone.0282884
• Publication Date: 2023-03-21T17:30:30Z
• Authors: Nompilo Moyo; Ee Laine Tay; James M. Trauer; Leona Burke; Justin Jackson; Robert J. Commons; Sarah C. Boyd; Kasha P. Singh; Justin T. Denholm
• Keywords: Extensively drug-resistant tuberculosis

Regionality is often a significant factor in tuberculosis (TB) management and outcomes worldwide. A wide range of context-specific factors may influence these differences change over time. We compared TB treatment regional metropolitan areas, considering demographic temporal trends affecting diagnosis outcomes.Retrospective analyses data for patients notified with Victoria, Australia, were conducted. The study delays outcomes. Multivariable Cox proportional hazard model performed to investigate the effect regionality TB. Six hundred eleven (7%) 8,163 (93%) areas between 1995 2019. Of 611 cases cohort, 401 (66%) overseas-born. Fifty-one percent overseas-born Victoria developed disease within five years arrival Australia. Four multidrug-resistant reported 97 areas. total 3,238 from 2012 2019 included survival analysis. time follow-up patient delay started at symptom onset date, event was presentation healthcare centre. For system delay, began centre, commenced on treatment. Cases extrapulmonary have non-significantly longer than (median 64 days versus 54 days, AHR = 0.8, 95% CI 0.6-1.0, P 0.094).Tuberculosis common among population, experienced non-significant minor commencement no apparent detriment Improving access LTBI reduce burden