“Acute kidney injury in critically ill patients with COVID–19: The AKICOV multicenter study in Catalonia”

• DOI: 10.1371/journal.pone.0284248
• Publication Date: 2023-04-14T17:42:49Z
• Authors: Arsenio De La Veg...; Ana Navas Pérez; Marcos Pérez-Carr...; María Torrens Sonet; Yolanda Diaz Buendia; Patricia Ortiz Ba...; Miguel Rodríguez ...; Joan Sabater Riera; Aitor Olmo-Isasmendi; Ester Vendrell Torra; María Álvarez Gar...; Mercedes Ibarz Vi...; Rosa María Catalá...; Iban Oliva Zelaya; Javier Pardos Chica; Conxita Rovira An...; Teresa M. Tomasa-...; Anna Baró Serra; Edward J. Casanova; Francisco J. Gonz...
• Keywords: Renal replacement therapy

This study describes the incidence, evolution and prognosis of acute kidney injury (AKI) in critical COVID-19 during first pandemic wave. We performed a prospective, observational, multicenter confirmed patients admitted to 19 intensive care units (ICUs) Catalonia (Spain). Data regarding demographics, comorbidities, drug medical treatment, physiological laboratory results, AKI development, need for renal replacement therapy (RRT) clinical outcomes were collected. Descriptive statistics logistic regression analysis development mortality used. A total 1,642 enrolled (mean age 63 (15.95) years, 67.5% male). Mechanical ventilation (MV) was required 80.8% 64.4% these patients, who prone position, while 67.7% received vasopressors. at ICU admission 28.4% increased 40.1% stay. 172 (10.9%) RRT, which represents 27.8% developed AKI. more frequent severe respiratory distress syndrome (ARDS) ARDS (68% vs 53.6%, p<0.001) MV (91.9% 77.7%, p<0.001), position frequently (74.8 61%, infections. hospital (48.2% 17.7% 51.1% 19%, p <0.001) respectively). an independent factor associated with (IC 1.587-3.190). Mortality higher RRT (55.8% 48.2%, <0.04). Conclusions There is high incidence critically ill disease it mortality, organ failure, nosocomial infections prolonged