Enteral nutrition management in critically ill adult patients and its relationship with intensive care unit-acquired muscle weakness: A national cohort study

• DOI: 10.1371/journal.pone.0286598
• Publication Date: 2023-06-07T17:34:53Z
• Authors: Ignacio Zaragoza-...; Susana Arias-Rivera; María Jesús Frade...; Joan Daniel Martí; Elisabet Gallart; Alicia San José-A...; Tamara Raquel Vel...; Eva Blazquez-Mart...; Marta Raurell-Tor...
• Keywords: Enteral administration

Objective To assess the incidence and determinants of ICU-acquired muscle weakness (ICUAW) in adult patients with enteral nutrition (EN) during first 7 days ICU mechanical ventilation for at least 48 hours. Methods A prospective, nationwide, multicentre cohort study a national network 80 ICUs. receiving invasive hours EN their stay were included. The primary outcome was ICUAW. secondary analysed, 3–7 stay, relationship between demographic clinical data to contribute onset ICUAW, identify whether energy protein intake can independently ICUAW degree compliance guidelines EN. Results 319 studied from 69 ICUs our country. 153/222 (68.9%; 95% CI [62.5%-74.7%]). Patients without showed higher levels active mobility (p = 0.018). logistic regression analysis no effect on or Overfeeding observed significant proportion patient-days, while more overfeeding (as per US guidelines) found among obesity than those (42.9% vs 12.5%; p<0.001). Protein deficient US/European 3–7. Conclusions high this patient cohort. Early associated lower Significant observed. However, alone insufficient explain onset. Relevance practice Low mobility, low suggest need train, update involve professionals nutritional care early mobilization patients.