Pan-cancer analysis of the intervertebral-disc-degeneration-related innate immunity gene NAIP

• DOI: 10.1371/journal.pone.0286647
• Publication Date: 2023-06-02T17:39:10Z
• Authors: Wen-Bin Xu; Vit Kotheeranurak; Ding-Qiang Chen; Nai-Kun Sun; Di-Xin Cai; Chien-Min Chen; Guang-Xun Lin; Gang Rui
• Keywords: Cancer Research; Databases, Factual; Innate Immunity to Viral Infection; Science; Immunology; Intervertebral Disc Degeneration; Biochemistry, Genetics and Molecular Biology; Health Sciences; Humans; Biology; Role of STAT3 in Cancer Inflammation and Immunity; Cancer; Immunology and Microbiology; Inflammation; FOS: Clinical medicine; Innate immune system; Q; Carcinoma; R; Immunity; Chromosome Mapping; Life Sciences; Immunity, Innate; Neuronal Apoptosis-Inhibitory Protein; Innate Immunity; 3. Good health; Immune system; Oncology; Medicine; Immune Responses; NF-?B Signaling in Inflammation and Cancer; Research Article

Background Intervertebral disc degeneration (IDD) is a progressive chronic condition that commonly causes low back pain. Cancer among the primary reasons for deaths worldwide. Our purpose was to identify characteristic genes of IDD and explore potential association between cancer. Methods Immune cell infiltration differentially expressed analysis were conducted utilizing data from GSE124272 database. Enrichment (DEGs) performed possible mechanisms underlying development. Moreover, weighted gene correlation network (WGCNA) applied select IDD-related hub genes. The immune-related key determined by intersecting DEGs, genes, immune Subsequently, machine learning models based on these built verify RNA sequencing clinical 33 carcinoma categories obtained Genome Atlas (TCGA). NAIP expression prognosis calculated using Kaplan-Meier analysis. To gain deeper understanding impact in tumor immunotherapy, two immunotherapeutic biomarkers explored. Ultimately, response investigated independent cohorts. Results identified as an normal intervertebral tissue. In certain categories, levels elevated (4/33) significantly correlated respective stage (4/21). Survival revealed have prognostic significance different cancer types. Generally, presented strong with modulators. may influence immunotherapy effects through mutational burden microsatellite instability. No remarkable found either cohort. Conclusion study first gene. Pan-cancer could serve novel marker therapeutic target variety reducing risk patients.