The effect of diabetes mellitus on COVID-19 mortality among patients in a tertiary-level hospital in Bandung, Indonesia

• DOI: 10.1371/journal.pone.0286797
• Publication Date: 2023-06-15T17:48:23Z
• Authors: Maya Kusumawati; Raspati Cundarani...; Zuhaira Husna Fatma; Evan Susandi; Hikmat Permana; Nanny Natalia Mul...; Arto Yuwono Soeroto; Begawan Bestari; Basti Andriyoko; Bachti Alisjahbana; Yovita Hartantri
• Keywords: Univariate analysis

Immune system dysregulation in people with diabetes mellitus (DM) increases the risk of acquiring severe infection. We compared clinical characteristics and laboratory parameters coronavirus disease 2019 (COVID-19) patients without DM estimated effect on mortality among COVID-19 patients. A retrospective cohort study collecting patients' demographic, characteristics, treatment outcomes from medical records was conducted a hospital Bandung City March to December 2020. Univariable multivariable logistic regression performed determine association between death. total 664 positive real-time reverse transcription polymerase chain reaction for acute respiratory syndrome 2 were included this study, whom 147 DM. Half presented HbA1c ≥10%. more likely present comorbidities critical conditions at admission (P <0.001). Laboratory such as neutrophil-lymphocyte count ratio, C-reactive protein, D-dimer, ferritin, lactate dehydrogenase higher group. In univariate analysis, variables associated death severity baseline, neurologic disease, DM, age ≥60 years, hypertension, cardiovascular chronic kidney disease. remained (aOR 1.82; 95% CI 1.13-2.93) after adjustment sex, age, conclusion, are very high HbA1c, comorbidities, severe-critical illness. Chronic inflammation may be aggravated by disruption immune response caused COVID-19, leading worse results poor outcomes.