Modifiable risk factors of major depressive disorder: A Mendelian randomization study

• DOI: 10.1371/journal.pone.0289419
• Publication Date: 2023-08-03T17:38:53Z
• Authors: Xiaofei Zheng; Li Tong; Chong Zhang; Chaoyang Zhang; Chao Zhang; Bangbei Wan
• Keywords: Mendelian Randomization; Genome-wide Association Study

Identifying modifiable risk factors early on is essential to prevent major depressive disorder (MDD). This study systematically investigated the causal relationship between 19 and MDD. Single-nucleotide polymorphisms (SNPs) associated with potentially were screened via genome-wide association (GWAS) enrolling individuals of European descent. Summary-level data for MDD (59,851 cases 113,154 controls) extracted from UK Biobank. The inverse-variance-weighted (IVW) method was utilized as primary analysis. Sensitivity analyses performed using MR-Egger method, Maximum likelihood MR-pleiotropy residual sum outlier (MR-PRESSO) MR-robust adjusted profile score (MR-RAPS) method. regression, heterogeneity tests, pleiotropy leave-one-out tests also analyze sensitivity. MR Steiger test used verify directionality exposure outcome. Genetically predicted smoking initiation increased ( P = 6.00E-09), while status: never past tobacco decreased (all < 0.01). In addition, education level inversely instrumented sleeplessness/insomnia, daytime naps, nap during day positively related Personal feelings, including guilt, hurt, tension, worry too long after an embarrassing experience, had a suggestive 0.000). remaining five all causally MDD, neuroticism, neuroticism scores, body mass index (BMI), average total household income before tax, types physical activity in last 4 weeks All main hypothesis this that identifying intervening these could be beneficial prevention treatment further reduce mortality economic burden.