Cetylpyridinium chloride and chlorhexidine show antiviral activity against Influenza A virus and Respiratory Syncytial virus in vitro

• DOI: 10.1371/journal.pone.0297291
• Publication Date: 2024-02-16T18:25:18Z
• Authors: Marina Rius-Salvador; Maria Jesús Garcí...; Luciana Rusu; Manuel Bañó-Polo; Rubén León; Ron Geller; Ismael Mingarro; Luis Martinez-Gil
• Keywords: Cetylpyridinium chloride; Infectivity; Feline calicivirus

Background The oral cavity is the site of entry and replication for many respiratory viruses. Furthermore, it source droplets aerosols that facilitate viral transmission. It thought appropriate hygiene alters infectivity might reduce spread viruses contribute to infection control. Materials methods Here, we analyzed antiviral activity cetylpyridinium chloride (CPC), chlorhexidine (CHX), three commercial CPC CHX-containing mouthwash preparations against Influenza A virus Respiratory syncytial virus. To do so aforementioned compounds were incubated with or Next, viability treated particles. Results Our results indicate CHX decrease both Syncytial in vitro between 90 99.9% depending on concentration. Likewise, up 99.99% effective decreasing . Conclusion use a containing alone combination represent cost-effective measure limit enveloped infecting cavity, aiding reducing findings may stimulate future clinical studies evaluate effects transmissions.