Effect of an eight-week high-intensity interval training programme on circulating sphingolipid levels in middle-aged adults at elevated cardiometabolic risk (SphingoFIT)—Protocol for a randomised controlled exercise trial

• DOI: 10.1371/journal.pone.0302477
• Publication Date: 2024-05-08T17:30:01Z
• Authors: Justin Carrard; Manuel Hofer; Luisa Prechtl; Eva Fleischlin; Manuel Huber; Hector Gallart-Ayala; Tony Teav; Denis Infanger; Christoph Höchsmann; Karsten Koehler; Timo Hinrichs; Henner Hanssen; Julijana Ivanisevic; Arno Schmidt-Truc...
• Keywords: Sphingolipid

Evidence indicates that sphingolipid accumulation drives complex molecular alterations promoting cardiometabolic diseases. Clinically, it was shown sphingolipids predict risk independently of and beyond traditional biomarkers such as low-density lipoprotein cholesterol. To date, little is known about therapeutic modalities to lower levels. Exercise, a powerful means prevent treat diseases, promising modality mitigate levels in cost-effective, safe, patient-empowering manner.