Blood glucose and lactate levels as early predictive markers in patients presenting with cardiogenic shock: A retrospective cohort study

• DOI: 10.1371/journal.pone.0306107
• Publication Date: 2024-07-25T17:37:44Z
• Authors: Hannah Billig; Muntadher Al Zaidi; Florian Quacken; Jan Görtzen-Patin; Philip Roger Goody; Ingo Gräff; Georg Nickenig; Sebastian Zimmer; Adem Aksoy
• Keywords: Male; Blood Glucose; Science; Q; R; Shock, Cardiogenic; Myocardial Infarction; Middle Aged; Prognosis; ROC Curve; Medicine; Humans; Female; Lactic Acid; Hospital Mortality; Biomarkers; Research Article; Aged; Retrospective Studies

Lactate and glucose are widely used biochemical parameters in current predictive risk scores for cardiogenic shock. Data regarding the relationship between lactate levels shock limited. Thus, we aimed to analyze as early markers in-hospital mortality In this retrospective cohort study, 312 patients presenting with a tertiary-care hospital 2016 2018 were included. Apparent was defined hypoperfusion hemodynamic compromise marker increase due diminished tissue perfusion, corresponding SCAI stages. In-hospital assessed primary endpoint. The median age of study population 71 (60-79) years etiology acute myocardial infarction 45.8%. Overall 67.6%. receiver operating curve analysis, area under receiver-operating (AUC) prediction higher (AUC: 0.757) than 0.652). Both values significantly associated outcome (groups created best cutoff obtained from Youden index). Correlation analysis showed significant non-linear association both values. multivariable stepwise Cox regression remained an independent predictor mortality, whilst glucose, despite being implicated energy metabolism, not independently mortality. Together, these data suggest that at admission is superior apparent Glucose