Loss of Mfn1 but not Mfn2 enhances adipogenesis

• DOI: 10.1371/journal.pone.0306243
• Publication Date: 2024-12-31T18:49:01Z
• Authors: Jake P. Mann; Luis Carlos Tábara; Satish Patel; Pushpa Pushpa; Anna Alvarez-Guaita; Liang Dong; Afreen Haider; Koini Lim; Panna Tandon; Fabio Scurria; James E. N. Minchin; Stephen O’Rahilly S.; Daniel J. Fazakerley; Julien Prudent; Robert K. Semple; David B. Savage
• Keywords: MFN1; MFN2

A biallelic missense mutation in mitofusin 2 (MFN2) causes multiple symmetric lipomatosis and partial lipodystrophy, implicating disruption of mitochondrial fusion or interaction with other organelles adipocyte differentiation, growth and/or survival. In this study, we aimed to document the impact loss 1 (Mfn1) (Mfn2) on adipogenesis cultured cells.