The links between neuroinflammation, brain structure and depressive disorder: A cross-sectional study protocol

• DOI: 10.1371/journal.pone.0311218
• Publication Date: 2024-11-20T18:28:34Z
• Authors: Egle Milasauskiene; Julius Burkauskas; Simonas Jesmanas; Rymante Gleizniene; Vilmante Borutaite; Kristina Skemiene; Paulina Vaitkiene; Virginija Adomait...; Saulius Lukosevicius; Brigita Gradauskiene; Guy Brown; Vesta Steibliene
• Keywords: Post-hoc analysis; Depression

Introduction It is known that symptoms of major depressive disorder (MDD) are associated with neurodegeneration, lipopolysaccharide (LPS) can induce MDD, and blood LPS levels elevated in neurodegeneration. However, it not whether cytokine correlate cognition brain structure, this tested study. Methods analysis This cross-sectional study includes individuals MDD ( n = 100) a control group no one-year history mental 50). A comprehensive evaluation performed, including the collection basic sociodemographic information, data on smoking status, body mass index, course past treatment, comorbid diseases, current use medications. Diagnosis performed according to WHO’s [2019] International Classification Diseases related health problems by psychiatrist severity evaluated using Montgomery–Åsberg Depression Scale. The Cambridge Neuropsychological Test Automated Battery used evaluate cognitive functioning. Venous samples taken measure genetic inflammatory markers, multiparametric magnetic resonance imaging for blood-brain barrier permeability, structural neurometabolic changes. Descriptive inferential statistics, linear logistic regression, will be analyse relationships between plasma concentrations patients controls. proposed sample sizes suitable identifying significant differences groups, power analysis. Administrative information Trial registration: Clinicaltrials.gov NCT06203015 .