Proof of concept pilot study to assess the utility of magnetic resonance extra-cellular volume quantification to diagnose advanced liver disease in people with Cystic Fibrosis

• DOI: 10.1371/journal.pone.0318085
• Publication Date: 2025-03-04T18:33:11Z
• Authors: Daniel H. Tewkesbury; Jennifer A. Scott; Rowland J. Bright...; Sue Liong; Josephine Naish; Velauthan Rudrali...; Karen Piper Hanley; Andrew M. Jones; Varinder S. Athwal

Current diagnostic tools are limited in their ability to diagnose cystic fibrosis liver disease (CFLD) as is often focal nature. Magnetic resonance extracellular volume quantification (MRI ECV) the may have utility CFLD a more selective assessed and can be performed using equipment readily available clinical practice on standard MRI protocol. Healthy volunteers (HV), CF participants with no (CF-noLD) cirrhosis (CF-C) aged 18 years above had ECV measured 3T Siemens scanner. An additional retrospective analysis was calculate individuals who images obtained 1.5T scanner from previous study. 16 Mean (SD) 0.316 (0.058) for HV (n = 5), 0.297 (0.034) CF-noLD 5) 0.388 (0.067) CF-C 6 ). Post-hoc showed significant difference between (p 0.046). Of scanner, mean 0.269 (0.048) 8), 0.310 (0.037) 8) 0.362 (0.063) 2). Liver feasible adults results suggesting applicability across different types of A higher demonstrated potential tool those advanced CFLD. Further evaluation larger cohorts warranted.