Association of mean corpuscular volume with 28-day mortality in sepsis patients: A retrospective cohort study using eICU data

• DOI: 10.1371/journal.pone.0321213
• Publication Date: 2025-04-21T17:43:09Z
• Authors: Huizhen Tang; Mingli Qu; Miaomiao Xin; Tongqiang He
• Keywords: Quartile

Introduction The issue of mortality due to sepsis remains a significant concern in the field medicine. Previous researches have demonstrated an association between mean corpuscular volume (MCV) and from range diseases. objective this study was investigate relationship MCV risk large multicentre cohort. Method A retrospective cohort conducted using data eICU Collaborative Research Database 2014–2015. determined within initial 24 hours ICU admission, with patients subsequently classified into quartiles based on their levels. Multivariate regression models were employed correlation 28-day mortality, adjustments made for potential confounding factors such as age, sex, body mass index, vital signs comorbidities. To evaluate dose-response sepsis, smoothed curve fitting threshold effects analysis utilised. Results total 9,415 included rate 9.38% (883/9415). After adjusting variables, it found that odds ratio (OR) 1.11 (95% CI 1.01, 1.23, P=0.04) increased followed by each 1 fl increase MCV. fitted curves nonlinear positive mortality. inflection point level 83 fl. At <83 fl, there (OR 1.10, 95% 1.02, 1.17, P =0.004). Conclusions There is non-linear death sepsis. Clinicians should be aware changes indicator, especially high