ARACOV-02. Specialized nutritional intervention and telerehabilitation in patients with long COVID: Protocol of a randomized controlled trial

• DOI: 10.1371/journal.pone.0321811
• Publication Date: 2025-04-29T17:33:51Z
• Authors: Beatriz Carpallo-...; Carolina Jiménez-...; Sandra Calvo; Pilar Irún; Elena Kolesnyk-Su...; Ana Isabel Aller-...; Esther del Corral...
• Keywords: Telerehabilitation; Clinical endpoint

Background It is estimated that at least 10% of the population infected with SARS-CoV-2 develop Post COVID Condition, which characterized by a diverse array symptoms including dyspnea, fatigue, anxiety, depression, and deterioration in quality life. The virus can trigger an excessive immune response, release pro-inflammatory cytokines IL-6, IL-1, TNFα reactive oxygen species. Specialized Pro Resolving Mediators (SPMs) (17-HAD, 14-HAD 18_HEPE) could be useful Condition modulating inflammatory response. objective to determine change life, profile, functional capacity emotional variables group taking nutritional supplement plus telerehabilitation programme. Methods ARACOV-2 study double-blind, parallel-group, randomized control trial two parallel interventions: Nutritional vs placebo telerehabilitation. primary endpoint will life (EQ-5L-5D). intervention last 12 weeks daily intake omega-3 or supervised rehabilitation programme using Discussion This suggests SPMs supplementation combined may improve inflammation like fatigue patients. Both interventions have anti-inflammatory potential, their use enhance physical mental health outcomes. approach offers promising strategy for managing symptoms. Trial registration ClinicalTrials.gov NCT06063031