Transmission Pathways of Foot-and-Mouth Disease Virus in the United Kingdom in 2007

• DOI: 10.1371/journal.ppat.1000050
• Publication Date: 2008-04-17T22:12:06Z
• Authors: Eleanor M. Cottam; Jemma Wadsworth; Andrew E. Shaw; Rebecca J. Rowlands; Lynnette Goatley; Sushila Maan; Narender S. Maan; Peter P. C. Mertens; Katja Ebert; Yanmin Li; Eoin D. Ryan; Nicholas Juleff; Nigel P. Ferris; John W. Wilesmith; Daniel T. Haydon; Donald P. King; David J. Paton; Nick J. Knowles
• Keywords: Strain (injury)

Foot-and-mouth disease (FMD) virus causes an acute vesicular of domesticated and wild ruminants pigs. Identifying sources FMD outbreaks is often confounded by incomplete epidemiological evidence the numerous routes which can spread (movements infected animals or their products, contaminated persons, objects, aerosols). Here, we show that in United Kingdom August 2007 were caused a derivative FMDV O(1) BFS 1860, strain handled at two laboratories located on single site Pirbright Surrey. Genetic analysis complete viral genomes generated real-time reveals probable chain transmission events, predicting undisclosed premises, connecting second cluster September to those August. Complete genome sequence viruses conducted have identified initial intermediate these demonstrate value such techniques providing information useful contemporary control programmes.