Critical Role of IRF-5 in the Development of T helper 1 responses to Leishmania donovani infection

• DOI: 10.1371/journal.ppat.1001246
• Publication Date: 2011-01-06T22:24:41Z
• Authors: Andrea Paun; Rashmi Bankoti; Trupti Joshi; Paula M. Pitha; Simona Stäger
• Keywords: IRF1; Proinflammatory cytokine; TLR7; IRF5

The transcription factor Interferon Regulatory Factor 5 (IRF-5) has been shown to be involved in the induction of proinflammatory cytokines response viral infections and TLR activation play an essential role innate inflammatory response. In this study, we used experimental model visceral leishmaniasis investigate IRF-5 generation Th1 responses formation Th1-type liver granulomas Leishmania donovani infected mice. We show that TLR7-mediated is for development L. spleen during chronic infection. also demonstrate deficiency leads incapacity control infection smaller granulomas. Granulomas Irf5-/- mice are characterized by increased IL-4 IL-10 concomitant low iNOS expression. Collectively, these results identify as a critical molecular switch immune following reveal indirect regulation