Relative Contribution of Th1 and Th17 Cells in Adaptive Immunity to Bordetella pertussis: Towards the Rational Design of an Improved Acellular Pertussis Vaccine

• DOI: 10.1371/journal.ppat.1003264
• Publication Date: 2013-04-04T22:18:44Z
• Authors: Pádraig J. Ross; Caroline E. Sutton; Sarah Higgins; Aideen C. Allen; Kevin Walsh; Alicja Misiak; Ed C. Lavelle; Rachel M. McLoughlin; Kingston H. G. Mills
• Keywords: Whooping cough; Pertussis vaccine; Humoral immunity

Whooping cough caused by Bordetella pertussis is a re-emerging infectious disease despite the introduction of safer acellular vaccines (Pa). One explanation for this that Pa are less protective than more reactogenic whole cell (Pw) they replaced. Although induce potent antibody responses, and protection has been found to be associated with high concentrations circulating IgG against vaccine antigens, it not firmly established host induced mediated solely humoral immunity. The aim study was examine relative contribution Th1 Th17 cells in immunity infection B. immunization Pw use information help rationally design effective Pa. Our findings demonstrate both function or Pw. In contrast, current licensed Pa, administered alum as adjuvant, Th2 cells, but weak responses. We IL-1 signalling played central role alum-adsorbed induction cells. generated strong fully IL-4-defective mice, suggesting were dispensable. failed confer IL-17A-defective mice. Bacterial clearance Pa-induced recruitment lungs after challenge. Finally, an experimental could enhanced substituting TLR agonist induces promotes through IL-1β-induced IL-17A production, also reveal optimum requires Th1,