IL-23 supports host defense against systemic Candida albicans infection by ensuring myeloid cell survival

• DOI: 10.1371/journal.ppat.1008115
• Publication Date: 2019-12-30T18:48:50Z
• Authors: Selim Nur; Florian Sparber; Christina Lemberg; Eva Guiducci; Tiziano A. Schweizer; Pascale Zwicky; Burkhard Becher; Salomé LeibundGut...
• Keywords: Myelopoiesis; Systemic candidiasis

The opportunistic fungal pathogen Candida albicans can cause invasive infections in susceptible hosts and the innate immune system, particular myeloid cell-mediated immunity, is critical for rapid protection host survival during systemic candidiasis. Using a mouse model of human disease, we identified novel role IL-23 antifungal defense. IL-23-deficient mice are highly to infection with C. albicans. We found that this results from drastic reduction all subsets cells infected kidney, which turn leads overgrowth renal tissue injury. loss not due defect emergency myelopoiesis or recruitment newly generated site but, rather, consequence impaired at infection. In fact, absence functional pathway causes massive cell apoptosis upon Importantly, protects independently IL-23-IL-17 axis lymphocytes lymphoid cells. Instead, our suggest acts partially autocrine but cell-intrinsic manner within compartment promote Collectively, data highlight an unprecedented non-canonical securing cells, key maintaining sufficient numbers ensure efficient protection.